Part1：What is Magnolia officinalis extract?
Magnolia officinalis extract is a product extracted from the dried root bark, stem bark or branch bark of Magnolia officinalis, a plant of the Magnoliaceae family. The main components are phenol, volatile oil, alkaloids, etc. It has the functions of drying dampness and eliminating phlegm and removing qi from the lower qi. For dampness stagnation injury, epigastric vomiting and diarrhea, food accumulation of qi stagnation, abdominal distention and constipation, phlegm and cough.
Part2：The benefits of Magnolia officinalis extract
1. Muscle relaxation
The water extract of Magnolia officinalis has a significant curare-like effect, and its alcohol extract can reduce the grip strength, and has a strong inhibitory effect on the spasm induced by strychnine, picrotoxin and other drugs. It can relieve intestinal spasm caused by barium chloride and pilocarpine, and inhibit the contraction of isolated bronchial smooth muscle of guinea pigs caused by histamine. A water-soluble alkaloid isolated from Magnolia officinalis, honokidine (also known as magnoculine), has a relaxing effect on striated muscles and can block the transmission of impulses in the motor endplate, so it has a nerve-muscle blocking effect. . The dose of intravenous injection to make rabbits hang their heads is 13.8mg.
2. Central inhibition
The ether extract of Magnolia officinalis can reduce the spontaneous activity of mice and resist the excitement caused by methamphetamine or apomorphine, and honokiol and isohonokiol also have significant central inhibitory effects. Honokiol can completely inhibit the spinal cord reflex in mice, ether extract 0.25～1g
3. Effects on the digestive system
Magnolia officinalis 50% ethanol extract has a significant inhibitory effect on gastric mucosal ulcer with hydrochloric acid ethanol, and one of its active components is determined to be honokiol and honokiol.
4. Antibacterial effect
Magnolia decoction has antibacterial effect on gram-positive bacteria such as staphylococcus, pneumococcus, hemolytic streptococcus, and gram-negative bacteria such as Shigella, typhi, Escherichia coli, and Bacillus subtilis in vitro. The antibacterial effects of 62 kinds of traditional Chinese medicine powders on Staphylococcus albus, Bacillus subtilis, Escherichia coli and Bacillus typhi were checked on the plate, especially Magnolia officinalis was the strongest. Experiments show that Magnolia officinalis also has a certain inhibitory effect on pathogenic dermatophytes.
5. Exciting smooth muscle action
Magnolia decoction has an excitatory effect on the isolated intestine and bronchus of rabbits and bronchial smooth muscle of guinea pigs. Magnolia officinalis decoction at a concentration of 1:166 in the isolated mouse intestinal tube showed an excitatory effect.
6. Anti-tumor effect
The three extractive components lignan, magnolol, and honokiol in Magnolia officinalis and the monoterpene magnoliol are 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced Epstein - Antagonist of Barr virus early antigen (EBv-EA) activation. Honokiol and its hydroxymethyl derivatives have obvious inhibitory effects on stage II skin tumors in mice.
7. Antihypertensive effect
When the dose of honokidine is lower than the muscle relaxant dose, it has obvious antihypertensive effect, and this effect cannot be resisted by antihistamines, indicating that it is not caused by the release of histamine, and the blood pressure time course of intravenous injection is maintained for about 10 ~ 15 minutes, intramuscular injection can be maintained for more than 1 hour. Magnolia officinalis tincture water-soluble to anesthetized cats, rabbits intravenous or intramuscular injection has antihypertensive effect, and increase the heart rate.
8. Anti-caries effect
Magnolia bark extract was tested for bacteriostasis on cariogenic pathogen Streptococcus mutans, and found to have efficient and rapid bactericidal effect.
9.Anti-ulcer effect
Magnolia officinalis 5% ethanol extract showed a significant inhibitory effect on mucosal ulcers. Magnolol has inhibitory effects on Shay's pyloric ligation, water immersion stress gastric ulcer, and histamine-induced duodenal spasm.
10. Antispasmodic effect
Magnolia ethyl ether extract can reduce grip strength, and has a strong inhibitory effect on spasticity induced by drugs such as strychnine, picrotoxin, and pentylenetetrazole.
